Nadine frontpage

Nanosystems for early Diagnosis of Neurodegenerative Diseases


Martin Dufva
Groupleader, Associate Professor
DTU Health Tech
+45 51 33 37 53

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The NADINE project aims at the development of a diagnostic tool able to detect in blood as early as possible, and at a cost compatible with large scale screening, emerging neurodegenerative diseases (e.g. Alzheimer’s Disease), and thus aid in the selection of the best treatment. None of current methods is able to achieve such a differentiation. The project thus has an immense impact for health, quality of life and economy. 

The NADINE project will involve radical innovations in microfluidics, nanoparticles, electrophoresis protein analyses, analytic chemistry and bioinformatics. It will develop and integrate new technologies towards a fully automated lab-on-chip system for the simultaneous quantitative analysis of a multiplicity of proteins, peptides and their variants, down to concentrations in the picomolar range directly from plasma. In particular, the system will, for the first time, combine in a single automated operation protein microarray and microchannel high resolution electrophoresis directly from clinical samples.

The project involves a multidisciplinary consortium of technology developers, three leading biomedical groups in clinical neuroscience for definition of specifications and end-user pre-clinical validation, three research-oriented SMEs in biotechnology, nanosensing and microfluidics and a pharmaceutical company.

The expected final result of NADINE is a prototype instrument and methods for the early differential diagnosis of neurodegenerative diseases based on multimodal biomarkers signature.

The project is financially based on a EU contribution of the Nano-, micro- and Production Technology (NMP) priority within the 7th Framework programme. Nadine has 17 partners, and is headed by DTU Nanotech, Denmark. It started 1 September 2010 and terminates in 2015.

  Université Paris-Sud Univerzita Pardubice Institute of Macromolecular Chemistry 
Institut Curie University of Ulm  Universitätklinikum Essen  
FLUIGENT  Moravian - Biotechnology Ltd  KTH  Itä-suomen Yliopisto 
Instituto di Chimica del Ricinoscimento Moleculare  IT   Instituto Catalá de Nanotecnologia  ES   Association pour la Recherche et le Développement des Méthodes et Processus Industriels  Armines ARM  FR  RAMBØLL 


16 JANUARY 2021