Peer-reviewed articles

2016

Neurofilaments in the diagnosis of motoneurondiseases: a prospective study on 455 patients

Petra Steinacker, Emily Feneberg, Jochen Weishaupt, Johannes Brettschneider,Hayrettin Tumani, Peter M Andersen, Christine A F von Arnim, Sarah Böhm,Jan Kassubek, Christian Kubisch, Dorothée Lulé, Hans-Peter Müller,Rainer Muche, Elmar Pinkhardt, Patrick Oeckl, Angela Rosenbohm,Sarah Anderl-Straub, Alexander E Volk, Patrick Weydt, Albert C Ludolph,Markus Otto
J Neurol Neurosurg Psychiatry 2015;0:1–9

DOI: 10.1136/jnnp-2015-311387 PubMed: 26296871

2015

 

Selective handling of droplets in a microfluidic device using magnetic rails

Bruno Teste, Nicolas Jamond, Davide Ferraro, Jean-Louis Viovy, Laurent Malaquin
Microfluidics and Nanofluidics, July 2015, Volume 19, Issue 1, pp 141-153

DOI: 10.​1007/​s10404-015-1556-6
 

Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia

Freischmidt, A., T. Wieland, B. Richter, W. Ruf, V. Schaeffer, K. Muller, N. Marroquin, F. Nordin, A. Hubers, P. Weydt, S. Pinto, R. Press, S. Millecamps, N. Molko, E. Bernard, C. Desnuelle, M. H. Soriani, J. Dorst, E. Graf, U. Nordstrom, M. S. Feiler, S. Putz, T. M. Boeckers, T. Meyer, A. S. Winkler, J. Winkelman, M. de Carvalho, D. R. Thal, M. Otto, T. Brannstrom, A. E. Volk, P. Kursula, K. M. Danzer, P. Lichtner, I. Dikic, T. Meitinger, A. C. Ludolph, T. M. Strom, P. M. Andersen and J. H. Weishaupt
Nat Neurosci. 2015 May;18(5):631-6

DOI: 10.1038/nn.4000 PubMed: 25803835
 

The role of TREM2 R47H as a risk factor for Alzheimer's disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and Parkinson's disease

Lill, C. M., A. Rengmark, L. Pihlstrom, I. Fogh, A. Shatunov, P. M. Sleiman, L. S. Wang, T. Liu, C. F. Lassen, E. Meissner, P. Alexopoulos, A. Calvo, A. Chio, N. Dizdar, F. Faltraco, L. Forsgren, J. Kirchheiner, A. Kurz, J. P. Larsen, M. Liebsch, J. Linder, K. E. Morrison, H. Nissbrandt, M. Otto, J. Pahnke, A. Partch, G. Restagno, D. Rujescu, C. Schnack, C. E. Shaw, P. J. Shaw, H. Tumani, O. B. Tysnes, O. Valladares, V. Silani, L. H. van den Berg, W. van Rheenen, J. H. Veldink, U. Lindenberger, E. Steinhagen-Thiessen, S. Consortium, S. Teipel, R. Perneczky, H. Hakonarson, H. Hampel, C. A. von Arnim, J. H. Olsen, V. M. Van Deerlin, A. Al-Chalabi, M. Toft, B. Ritz and L. Bertram
Alzheimers Dement. 2015 Apr 30.

DOI: 10.1016/j.jalz.2014.12.009 PubMed: 25936935
 

Effects of Alzheimer's disease-associated risk loci on cerebrospinal fluid biomarkers and disease progression: a polygenic risk score approach

Martiskainen H, Helisalmi S, Viswanathan J, Kurki M, Hall A, Herukka SK, Sarajärvi T, Natunen T, Kurkinen KM, Huovinen J, Mäkinen P, Laitinen M, Koivisto AM, Mattila KM, Lehtimäki T, Remes AM, Leinonen V, Haapasalo A, Soininen H, Hiltunen M
J Alzheimers Dis. 2015;43(2):565-73

DOI: 10.3233/JAD-140777 PubMed: 25096612
   

Apolipoprotein E genotype and the diagnostic accuracy of cerebrospinal fluid biomarkers for Alzheimer disease

Lautner R, Palmqvist S, Mattsson N, Andreasson U, Wallin A, Pålsson E, Jakobsson J, Herukka SK, Owenius R, Olsson B, Hampel H, Rujescu D, Ewers M, Landén M, Minthon L, Blennow K, Zetterberg H, Hansson O; Alzheimer’s Disease Neuroimaging Initiative
JAMA Psychiatry. 2014 Oct;71(10):1183-91 

DOI: 10.1001/jamapsychiatry.2014.1060 PubMed: 25162367
   

The effect of TOMM40 poly-T repeat lengths on age of onset and cerebrospinal fluid biomarkers in Finnish Alzheimer's disease patients

Helisalmi S, Hall A, Meriläinen EH, Väisänen V, Koivisto AM, Herukka SK, Laitinen M, Soininen H, Hiltunen M
Neurodegener Dis. 2014;14(4):204-8 

DOI: 10.1159/000367994 PubMed: 25500937
 

Cerebrospinal fluid biomarkers in trials for Alzheimer and Parkinson diseases

Lleó A, Cavedo E, Parnetti L, Vanderstichele H, Herukka SK, Andreasen N, Ghidoni R, Lewczuk P, Jeromin A, Winblad B, Tsolaki M, Mroczko B, Visser PJ, Santana I, Svenningsson P, Blennow K, Aarsland D, Molinuevo JL, Zetterberg H, Mollenhauer B
Nat Rev Neurol. 2015 Jan;11(1):41-55

DOI: 10.1038/nrneurol.2014.232 PubMed: 25511894
 

Prevalence and prognosis of Alzheimer's disease at the mild cognitive impairment stage

Vos SJ, Verhey F, Frölich L, Kornhuber J, Wiltfang J, Maier W, Peters O, Rüther E, Nobili F, Morbelli S, Frisoni GB, Drzezga A, Didic M, van Berckel BN, Simmons A, Soininen H,Kłoszewska I, Mecocci P, Tsolaki M, Vellas B, Lovestone S, Muscio C, Herukka SK, Salmon E, Bastin C, Wallin A, Nordlund A, de Mendonça A, Silva D, Santana I, Lemos R,Engelborghs S, Van der Mussele S; Alzheimer’s Disease Neuroimaging Initiative, Freund-Levi Y, Wallin ÅK, Hampel H, van der Flier W, Scheltens P, Visser PJ
Brain. 2015 May;138(Pt 5):1327-38

DOI: 10.1093/brain/awv029 PubMed: 25693589
 

Amyloid-β and Tau Dynamics in Human Brain Interstitial Fluid in Patients with Suspected Normal Pressure Hydrocephalus

Herukka SK, Rummukainen J, Ihalainen J, von Und Zu Fraunberg M, Koivisto AM, Nerg O, Puli LK, Seppälä TT, Zetterberg H, Pyykkö OT, Helisalmi S, Tanila H, Alafuzoff I, Hiltunen M, Rinne J, Soininen H, Jääskeläinen JE, Leinonen V
J Alzheimers Dis. 2015 May 7;46(1):261-9 

DOI: 10.3233/JAD-142862 PubMed: 25720406
   

Cerebrospinal fluid biomarkers for Alzheimer's disease in patients with frontotemporal lobar degeneration and amyotrophic lateral sclerosis with the C9ORF72 repeat expansion

Kämäläinen A, Herukka SK, Hartikainen P, Helisalmi S, Moilanen V, Knuuttila A, Jansson L, Tienari PJ, Remes AM
Dement Geriatr Cogn Disord. 2015;39(5-6):287-93

DOI: 10.1159/000371704 PubMed: 25791939
 

CSF biomarkers for the differential diagnosis of Alzheimer's disease. A large-scale international multicenter study

Ewers M, Mattsson N, Minthon L, Molinuevo JL, Antonell A, Popp J, Jessen F, Herukka SK, Soininen H, Maetzler W, Leyhe T, Bürger K, Taniguchi M, Urakami K, Lista S, Dubois B, Blennow K, Hampel H
Alzheimers Dement. 2015 Mar 21

DOI: 10.1016/j.jalz.2014.12.006 pii: S1552-5260(15)00063-1 PubMed: 25804998
   

Prevalence ofcerebral amyloid pathology in persons without dementia: a meta-analysis

Willemijn J. Jansen, Rik Ossenkoppele, Dirk L. Knol, Betty M. Tijms, Philip Scheltens, Frans R. J. Verhey, Pieter Jelle Visser, and the Amyloid Biomarker Study Group
JAMA. 2015 May 19;313(19):1924-38.

DOI: 10.1001/jama.2015.4668 PubMed: 25988462
   

The CERAD Neuropsychological Battery in Patients withFrontotemporal Lobar Degeneration

Haanpää RM, Suhonen NM, Hartikainen P, Koivisto AM, Moilanen V, Herukka SK, Hänninen T, Remes AM
Dement Geriatr Cogn Dis Extra. 2015 Apr 14;5(1):147-54

DOI: 10.1159/000380815 PubMed: 25999981
   

Chasing the effects of pre-analytical confounders – a multicenter study on CSF-AD biomarkers

Leitão MJ, Baldeiras I, Herukka SK, Pikkarainen M, Leinonen V, Simonsen AH, Perret-Liaudet A, Fourier A, Quadrio I, Veiga PM, de Oliveira CR
Front Neurol. 2015 Jul 8;6:153

DOI: 10.3389/fneur.2015.00153 PubMed: 26217300
   

The utility ofα-synuclein as biofluid marker in neurodegenerative diseases: a systematic review of the literature

Simonsen AH, Kuiperij B, Ali El-Agnaf OM, Engelborghs S, Herukka SK, Parnetti L, Rektorova I, Vanmechelen E, Kapaki E, Verbeek M, Mollenhauer B
Biomark Med. 2015 Aug 28

PubMed: 26314196
 

Use of amyloid-PET to determine cutpoints for CSF markers: A multicenter study

Zwan MD, Rinne JO, Hasselbalch SG, Nordberg A, Lleó A, Herukka SK, Soininen H, Law I, Bahl JM, Carter SF, Fortea J, Blesa R, Teunissen CE, Bouwman FH, van Berckel BN, Visser PJ
Neurology. 2015 Oct 14

pii: 10.1212/WNL.0000000000002081 PubMed: 26468410
 

An integrated microfluidic chip for immunocapture, preconcentration and separation of β-amyloid peptide

Reza M. Mohamadi, Zuzana Svobodova, Zuzana Bilkova, Markus Otto, Myriam Taverna, Stephanie Descroix, and Jean-Louis Viovy
Biomicrofluidics 9, 054117 (2015)

DOI: 10.1063/1.4931394 PubMed: 26487903
 

Application of trypsin Fe3O4@SiO2 core/shell nanoparticles for protein digestion

Marcela Slováková , Miloš Sedlák , Barbora Křížková , Rudolf Kupčík , Roman Bulánek , Lucie Korecká , Čestmír Drašar , Zuzana Bílková
Process Biochemistry, 379, 1-11

DOI: 10.1016/j.procbio.2015.09.002
   

Calf thymus histone-conjugated magnetic poly(2-oxoethyl methacrylate) microspheres for affinity isolation of anti-histone IgGs from blood serum of patients with systemic lupus erythematosus

D. Horák, Z. Plichta, M. Starykovych, S. Myronovskij, Y. Kit, V. Chopyak and R. Stoika
RSC Adv., 2015, 5, 63050-63055

DOI: 10.1039/C5RA09280A Article in PDF
 

Nanoparticles-based nanochannels assembled on a plastic flexible substrate for label-free immunosensing

Alfredo de la Escosura-Muñiz, Marisol Espinoza-Castañeda, Madoka Hasegawa, Laetitia Philippe, Arben Merkoçi
Nano Research, April 2015, Volume 8, Issue 4, pp 1180-1188

DOI: 10.1007/s12274-014-0598-5
 

Nanochannel array device operating through Prussian blue nanoparticles for sensitive label-free immunodetection of a cancer biomarker

Marisol Espinoza-Castañeda, Alfredo de la Escosura-Muñiz, Alejandro Chamorro, Carmen de Torres, and Arben Merkoçi
Biosensors and Bioelectronics, Volume 67, 15 May 2015, Pages 107–114

DOI: 10.1016/j.bios.2014.07.039 PubMed: 25103338
 

Tuning capillary surface properties by charged polymeric coatings

Laura Sola and Marcella Chiari
Journal of Chromatography A, Volume 1414, 2 October 2015, Pages 173–181

DOI: 10.1016/j.chroma.2015.08.032 PubMed: 26338212
 

Digital detection of biomarkers assisted by nanoparticles: application to diagnostics

Marina Cretich, George G. Daaboul, Laura Sola, M. Selim Ünlü, and Marcella Chiari
Trends in Biotechnology, Volume 33, Issue 6, June 2015, Pages 343–351

DOI: 10.1016/j.tibtech.2015.03.002
   

Detection and Differentiation of Threonine- and Tyrosine-Monophosphorylated Forms of ERK1/2 by Capillary Isoelectric Focusing-Immunoassay

Inga Kraus, Daniela Besong Agbo, Markus Otto, Jens Wiltfang, and Hans Klafki
Scientific Reports 5, Article number: 12767 (2015)

DOI: 10.1038/srep12767 Article in PDF PubMed: 26235103
 

Magneto-immunocapture with on-bead fluorescent labeling of amyloid-β peptides: towards a microfluidized-bed-based operation

Thanh Duc Mai Iago Pereiro Mohamed Hiraoui,  Jean-Louis Viovy Stéphanie Descroix Myriam Taverna, and  Claire Smadja
Analyst, 2015,140, 5891-5900

DOI: 10.1039/C5AN01179E PubMed: 26206107


 

Alzheimer’s disease biomarkers detection in human samples by efficient capturing through porous magnetic microspheres and labelling with electrocatalytic gold nanoparticles

de la Escosura-Muñiz A., Plichta Z., Horák D., Merkoçi A.
Biosens. Bioelectron. 67, 162-169 (2015)

DOI: 10.1016/j.bios.2014.07.086 PubMed: 25153932

2014

   

Protease-resistant SOD1 aggregates in amyotrophic lateral sclerosis demonstrated by paraffin-embedded tissue (PET) blot

Steinacker P, Berner C, Thal DR, Attems J, Ludolph AC, Otto M.
Acta Neuropathol Commun. 2014 Aug 28;2:130

DOI: 10.1186/s40478-014-0130-x PubMed: 25159221
   

Intact protein analysis of ubiquitin in cerebrospinal fluid by multiple reaction monitoring reveals differences in Alzheimer's disease and frontotemporal lobar degeneration

Oeckl, P., P. Steinacker, C. A. von Arnim, S. Straub, M. Nagl, E. Feneberg, J. H. Weishaupt, A. C. Ludolph and M. Otto
J Proteome Res. 2014 Nov 7;13(11):4518-25

DOI: 10.1021/pr5006058 PubMed: 25091646
 

Multicentre quality control evaluation of different biomarker candidates for amyotrophic lateral sclerosis

Lehnert, S., J. Costa, M. de Carvalho, J. Kirby, M. Kuzma-Kozakiewicz, C. Morelli, W. Robberecht, P. Shaw, V. Silani, P. Steinacker, H. Tumani, P. Van Damme, A. Ludolph and M. Otto
Amyotroph Lateral Scler Frontotemporal Degener. 2014 Sep;15(5-6):344-50

DOI: 10.3109/21678421.2014.884592 PubMed: 24575871
 

Limited role of free TDP-43 as a diagnostic tool in neurodegenerative diseases

Feneberg, E., P. Steinacker, S. Lehnert, A. Schneider, P. Walther, D. R. Thal, M. Linsenmeier, A. C. Ludolph and M. Otto
Amyotroph Lateral Scler Frontotemporal Degener. 2014 Sep;15(5-6):351-6

DOI: 10.3109/21678421.2014.905606 PubMed: 24834468
 

Comparison between clinical diagnosis and CSF biomarkers of Alzheimer disease in elderly patients with late onset psychosis: Helsinki Old Age Psychosis Study (HOPS)

Seppälä TT, Louhija UM, Appelberg B, Herukka SK, Juva K
Am J Geriatr Psychiatry. 2014 Sep;22(9):908-16

DOI: 10.1016/j.jagp.2012.08.020 PubMed: 23597931
 

Comparing predictors of conversion to Alzheimer's disease using the disease state index

Muñoz-Ruiz MÁ, Hall A, Mattila J, Koikkalainen J, Herukka SK, Vanninen R, Liu Y, Lötjönen J, Soininen H; Alzheimer’s Disease Neuroimaging Initiative
Neurodegener Dis. 2014;13(2-3):200-2

DOI: 10.1159/000354074 PubMed: 23969422
 

Blood plasma IgG Fc glycans are significantly altered in Alzheimer's disease and progressive mild cognitive impairment

Lundström SL, Yang H, Lyutvinskiy Y, Rutishauser D, Herukka SK, Soininen H, Zubarev RA
J Alzheimers Dis. 2014;38(3):567-79

DOI: 10.3233/JAD-131088 PubMed: 24028868
 

Prognostic polypeptide blood plasma biomarkers of Alzheimer's disease progression

Yang H, Lyutvinskiy Y, Herukka SK, Soininen H, Rutishauser D, Zubarev RA
J Alzheimers Dis. 2014;40(3):659-66 

DOI: 10.3233/JAD-132102 PubMed: 24503613
 

Cerebrospinal fluid biomarker and brain biopsy findings in idiopathic normal pressure hydrocephalus

Pyykkö OT, Lumela M, Rummukainen J, Nerg O, Seppälä TT, Herukka SK, Koivisto AM, Alafuzoff I, Puli L, Savolainen S, Soininen H, Jääskeläinen JE, Hiltunen M, Zetterberg H, Leinonen V
 2014 Mar 17;9(3):e91974

DOI: 10.1371/journal.pone.0091974 PubMed: 24638077
 

The cerebrospinal fluid "Alzheimer profile": easily said, but what does it mean?

Duits FH, Teunissen CE, Bouwman FH, Visser PJ, Mattsson N, Zetterberg H, Blennow K, Hansson O, Minthon L, Andreasen N, Marcusson J, Wallin A, Rikkert MO, Tsolaki M, Parnetti L, Herukka SK, Hampel H, De Leon MJ, Schröder J, Aarsland D, Blankenstein MA, Scheltens P, van der Flier WM
Alzheimers Dement. 2014 Nov;10(6):713-723.e2

DOI: 10.1016/j.jalz.2013.12.023 PubMed: 24721526
 

Altered cerebrospinal fluid levels of amyloid β and amyloid precursor-like protein 1 peptides in Down's syndrome

Portelius E, Hölttä M, Soininen H, Bjerke M, Zetterberg H, Westerlund A, Herukka SK, Blennow K, Mattsson N
Neuromolecular Med. 2014 Jun;16(2):510-6 

DOI: 10.1007/s12017-014-8302-1 PubMed: 24740518
   

Exploring Alzheimer molecular pathology in Down's syndrome cerebrospinal fluid

Portelius E, Soininen H, Andreasson U, Zetterberg H, Persson R, Karlsson G, Blennow K, Herukka SK, Mattsson N
Neurodegener Dis. 2014;14(2):98-106

DOI: 10.1159/000358800 PubMed: 24992945
   

Design, Preparation, and Evaluation of a Fixed-Orientation Antibody/Gold-Nanoparticle Conjugate as an Immunosensing Label

Claudio Parolo, Alfredo de la Escosura-Muñiz, Ester Polo, Valeria Grazú, Jesús M. de la Fuente, and Arben Merkoçi
ACS Appl. Mater. Interfaces, 2013, 5 (21), pp 10753–10759

DOI: 10.1021/am4029153

 

Nanoparticles Based Electroanalysis in Diagnostics Applications

Arben Merkoçi
Electroanalysis, Volume 25, Issue 1, pages 15–27, January 2013

DOI: 10.1002/elan.201200476
 

Paper-based nanobiosensors for diagnostics

Claudio Parolo and Arben Merkoçi
Chem. Soc. Rev., 2013,42, 450-457

DOI: 10.1039/C2CS35255A PubMed: 23032871
 

Micromotor Enhanced Microarray Technology for Protein Detection

Eden Morales-Narváez, Maria Guix, Mariana Medina-Sánchez, Carmen C. Mayorga-Martinez, and Arben Merkoçi
Small, Volume 10, Issue 13, July 9, 2014, Pages 2542–2548

DOI: 10.1002/smll.201303068 PubMed: 24634101
 

An Inkjet-Printed Field-Effect Transistor for Label-Free Biosensing

Mariana Medina-Sánchez, Carme Martínez-Domingo, Eloi Ramon, and Arben Merkoçi
Advanced Functional Materials, Volume 24, Issue 40, pages 6291–6302, October 29, 2014

DOI: 10.1002/adfm.201401180
 

Alzheimer Disease Biomarker Detection Through Electrocatalytic Water Oxidation Induced by Iridium Oxide Nanoparticles

Lourdes Rivas, Alfredo de la Escosura-Muñiz, Josefina Pons, and Arben Merkoçi
Electroanalysis, Volume 26, Issue 6, pages 1287–1294, June 2014

DOI: 10.1002/elan.201400027
 

Capillary isoelectric focusing immunoassay as a new nanoscale approach for the detection of oligoclonal bands

  1. Steffen Halbgebauer, Ute Haußmann, Hans Klafki, Hayrettin Tumani, Jens Wiltfang, and Markus Otto
    ELECTROPHORESIS Volume 36, Issue 2, pages 355–362 (2014)
    DOI: 10.1002/elps.201400339 PubMed: 25348366
 

Suppression of apparent fluid flow in capillary isotachophoresis without recourse to capillary coating

Oukacine F, Taverna M
Anal Chem. 86(7): 3317-22 (2014)

DOI:  10.1021/ac403337j PubMed: 24624887
 

Neutral polymers as coatings for the high resolution electrophoretic separation of Aβ peptides on glass microchip

Kiarach Mesbah, Romain Verpillot , Marcella Chiari, Antoine Pallandre and Myriam Taverna
Analyst, 2014 

DOI: 10.1039/C4AN01296H PubMed: 25356444
 

Surface functionalized thiol-ene waveguides for fluorescence biosensing in microfluidic

Nikolaj Agentoft Feidenhans’l, Josiane P. Lafleur, Thomas Glasdam Jensen and Jörg P. Kutter
Electrophoresis 2014, 35 (2-3), pages 282–288   

DOI:10.1002/elps.201300271 PubMed: 23983194
 

Chemical engineering of self assembled alzheimer's peptide on silanized silicon surface

Mehdi Ammar, Claire Smadja, Dienaba Tandjigora, Meriam Azzouz, Jacky vigneron, Arnaud Etcheberry, Myriam Taverna and Elisabeth Dufour-Gergam
Langmuir, 2014, 30 (20), pp 5863–5872

DOI: 10.1021/la500695y PubMed: 24654702

Monodisperse carboxyl-functionalized poly(ethylene glycol)-coated magnetic poly(glycidyl methacrylate) microspheres: Application to the immunocapture of ß-amyloid peptides

Horák D., Hlídková H., Hiraoui M., Taverna M., Proks V., Mázl Chánová E., Smadja C., Kučerová Z
Macromol. Biosci. 14, 1590-1599 (2014)

DOI: 10.1002/mabi.201400249 PubMed: 25142028
   

PEGylation of magnetic poly (glycidyl methacrylate) microparticles for microfluidic bioassays

Kucerova J., Svobodova Z., Knotek P., Palarcik J., Vlcek M., Kincl M., Horak D., Autebert J., Viovy J.L., Bilkova Z.
Mater. Sci. Eng. C 40, 308-315 (2014)

DOI: 10.1016/j.msec.2014.04.011 PubMed: 24857498
   

Monodisperse superparamagnetic nanoparticles by thermolysis of Fe(III) oleate and mandelate complexes

Patsula V., Petrovský E., Kovářová J., Konefal R., Horák D.
Colloid Polym. Sci. 292, 2097-2110 (2014)

DOI: 10.1007/s00396-014-3236-6    
   

Magnetic poly(glycidyl methacrylate) microspheres for capture of proteins

Koubková J., Müller P., Hlídková H., Plichta Z., Proks V., Vojtěšek B., Horák D.
New Biotechnol. 31, 482-491 (2014)

 DOI: 10.1016/j.nbt.2014.06.004    PubMed: 24998890
   

Poly(glycidyl methacrylate)/silver nanocomposite microspheres as a radioiodine scavenger: Electrophoretic characterization of carboxyl- and amine-modified particles

Macková H., Oukacine F., Plichta Z., Hrubý M., Kučka J., Taverna M., Horák D.
J. Colloid Interface Sci. 421C, 146-153 (2014)

 DOI: 10.1016/j.jcis.2014.01.042    PubMed: 24594043
   

High fat diet induced isoform changes of the Parkinson's disease protein DJ-1

G Poschmann, K Seyfarth, D Besong Agbo, HW Klafki, J Rozman, W Wurst, J Wiltfang , HEMeyer, M Klingenspor, K Stühler
J Proteome Res. 13(5):2339-51 (2014)

DOI: 10.1021/pr401157k PubMed: 24646099
   

Magnetic microparticles post-synthetically coated by hyaluronic acid as an enhanced carrier for microfluidic bioanalysis

Holubova, L., Knotek, P., Palarcik, J., Cadkova, M., Belina, P., Vlcek, M., Korecka, L., Bilkova, Z.
Materials science and Engineering C. 44, 345-351 (2014)

DOI: 10.1016/j.msec.2014.08.039 PubMed: 25280714
   

Comparison of monoclonal antibodies suitable for immunomagnetic purification of native tau protein

Barbora Jankovičová, Lenka Hromádková, Rudolf Kupčík, Jitka Kašparová, Daniela Řípová and Zuzana Bílková
Scientific Papers of the University of Pardubice Series A, Faculty of Chemical Technology 20, 147-163 (2014)

 

Protein microarrays technology: how far off is routine diagnostics?

M. Cretich, F. Damin, M. Chiari
Analyst 139 (3): 528 - 542 (2014). Invited review.

DOI:10.1039/C3AN01619F PubMed: 24326290
 

Characterization of a new fluorescence-enhancing substrate for microarrays with femtomolar sensitivity

Cretich M., Galati C., Renna L., Condorelli GG., Gagni P., Chiari M.
Sensors and Actuators B 192, 15-22 (2014).

DOI:10.1016/j.snb.2013.09.119
 

Universal hydrophilic coating of thermoplastic polymers currently used in microfluidics

Zilio C., Sola L., Damin F., Faggioni L., Chiari M.
Biomedical Microdevices 16, 107-114 (2014)

DOI: 10.1007/s10544-013-9810-8 PubMed: 24037663

2013

 

A low cost and high throughput magnetic bead-based immuno-agglutination assay in confined droplets

Teste B, Ali-Cherif A, Viovy JL, Malaquin L.
Lab Chip. 2013 Jun 21;13(12):2344-9 

DOI: 10.1039/c3lc50353d PubMed: 23640128
 

New non-covalent strategies for stable surface treatment of thermoplastic chips

Perez-Toralla K, Champ J, Mohamadi MR, Braun O, Malaquin L, Viovy JL, Descroix S.
Lab Chip. 2013 Nov 21;13(22):4409-18

DOI: 10.1039/c3lc50888a PubMed: 24061577
 

GRN variant rs5848 reduces plasma and brain levels of granulin in Alzheimer's disease patients

Kämäläinen A, Viswanathan J, Natunen T, Helisalmi S, Kauppinen T, Pikkarainen M, Pursiheimo JP, Alafuzoff I, Kivipelto M, Haapasalo A, Soininen H, Herukka SK, Hiltunen M
J Alzheimers Dis. 2013;33(1):23-7

DOI: 10.3233/JAD-2012-120946 PubMed: 22890097

 

 

Influence of the blood-CSF-barrier function on S100B in neurodegenerative diseases

Steinacker, P., K. Weidehaas, L. Cepek, E. Feneberg, H. A. Kretzschmar and M. Otto
Acta Neurol Scand. 2013 Oct;128(4):249-56

DOI: 10.1111/ane.12113 PubMed: 23510454
 

Elevated glial fibrillary acidic protein levels in the cerebrospinal fluid of patients with narcolepsy

Feneberg, E., P. Steinacker, S. Lehnert, B. Bohm, G. Mayer and M. Otto
Sleep Medicine, Volume 14, Issue 7, July 2013, Pages 692–694

DOI: 10.1016/j.sleep.2013.04.013 PubMed: 23746601
 

The use of hydrophilic poly(N,N-dimethylacrylamide) for promoting engulfment of magnetic gamma-Fe2O3 nanoparticles by mammalian cells

Zasonska B.A., Boiko N., Horák D., Klyuchivska O., Macková H., Beneš M., Babič M., Trchová M., Hromádková J., Stoika R.
J Biomed Nanotechnol. 2013 Mar;9(3):479-91

PubMed: 23621005
   

CSF biomarkers for Alzheimer's pathology and the effect size of APOE ɛ4

Andreasson U, Lautner R, Schott JM, Mattsson N, Hansson O, Herukka SK, Helisalmi S, Ewers M, Hampel H, Wallin A, Minthon L, Hardy J, Blennow K, Zetterberg H
Mol Psychiatry. 2014 Feb;19(2):148-9 

DOI: 10.1038/mp.2013.18 PubMed: 23419830

 

 

Predicting AD conversion: comparison between prodromal AD guidelines and computer assisted PredictAD tool

Liu Y, Mattila J, Ruiz MÁ, Paajanen T, Koikkalainen J, van Gils M, Herukka SK, Waldemar G, Lötjönen J, Soininen H; Alzheimer's Disease Neuroimaging Initiative.
PLoS One. 2013;8(2):e55246

DOI: 10.1371/journal.pone.0055246 PubMed: 23424625
 

Disease state fingerprint in frontotemporal degeneration with reference to Alzheimer's disease and mild cognitive impairment

Muñoz-Ruiz MÁ, Hartikainen P, Hall A, Mattila J, Koikkalainen J, Herukka SK, Julkunen V, Vanninen R, Liu Y, Lötjönen J, Soininen H
J Alzheimers Dis. 2013;35(4):727-39 

DOI: 10.3233/JAD-122260 PubMed: 23455991

 

 

Genetic loci associated with Alzheimer's disease and cerebrospinal fluid biomarkers in a Finnish case-control cohort

Elias-Sonnenschein LS, Helisalmi S, Natunen T, Hall A, Paajanen T, Herukka SK, Laitinen M, Remes AM, Koivisto AM, Mattila KM, Lehtimäki T, Verhey FR, Visser PJ, Soininen H, Hiltunen M
 2013;8(4):e59676

DOI: 10.1371/journal.pone.0059676 PubMed: 23573206

 

 

CSF biomarker variability in the Alzheimer's Association quality control program

Mattsson N, Andreasson U, Persson S, Carrillo MC, Collins S, Chalbot S, Cutler N, Dufour-Rainfray D,Fagan AM, Heegaard NH, Robin Hsiung GY, Hyman B, Iqbal K, Kaeser SA, Lachno DR, Lleó A, Lewczuk P,Molinuevo JL, Parchi P, Regeniter A, Rissman RA, Rosenmann H, Sancesario G, Schröder J, Shaw LM,Teunissen CE, Trojanowski JQ, Vanderstichele H, Vandijck M, Verbeek MM, Zetterberg H, Blennow K;Alzheimer's Association QC Program Work Group.
Alzheimers Dement. 2013 May;9(3):251-61

DOI: 10.1016/j.jalz.2013.01.010 PubMed: 23622690
   

Progression of Alzheimer's disease during a three-year follow-up using the CERAD-NB total score: Kuopio ALSOVA study

Hallikainen I, Hänninen T, Fraunberg M, Hongisto K, Välimäki T, Hiltunen A, Karppi P, Sivenius J, Soininen H, Koivisto AM; ALSOVA study Group
Int Psychogeriatr. 2013 Aug;25(8):1335-44

DOI: 10.1017/S1041610213000653 PubMed: 23676340
   

[Early diagnosis of Alzheimer's disease]

Seppälä T, Herukka SK, Remes AM
Duodecim. 2013;129(19):2003-10

PubMed: 24218731
 

Development of a Capillary Isoelectric Focusing Immunoassay to Measure DJ-1 Isoforms in Biological Samples

Agbo D Besong, H Klafki, G Poschmann, K Seyfarth, J Genius, C Janßen, K Stühler, W Wurst, HE Meyer, M Klingenspor and J Wiltfang
Analytical Biochemistry Volume 443, Issue 2, 15 December 2013, Pages 197–204

DOI: 10.1016/j.ab.2013.09.013 PubMed: 24055619

On-chip magneto-immunoassay for Alzheimer's biomarker electrochemical detection by using quantum dots as labels

M. Medina-Sánchez, S. Miserere, E. Morales-Narváez, A. Merkoçi
Biosensors & Bioelectronics 54, 279–284 (2013)

DOI: 10.1016/j.bios.2013.10.069 PubMed: 24287417
   

A new controlled concept of immune-sensing platform for specific detection of Alzheimer's biomarkers

Ammar M., Smadja C., Giang Thi Phuong L., Vigneron J., Etcheberry A., Taverna M., Dufour-Gergam E.
Biosens. Bioelectron. 40(1): 329-35 (2013)

DOI: 10.1016/j.bios.2012.07.072    PubMed: 22981833
   

Novel Fluorescent microarray platforms: a case study in neurodegenerative disorders

Cretich M., Sola L., Gagni P., Chiari M.
Expert Reviews of Molecular Diagnostics 13, 863-873, (2013)

DOI: 10.1586/14737159.2013.849574 PubMed: 24151850
   

Dot-ELISA affinity test: An easy, low-cost method to estimate binding activity of monoclonal antibodies

Svobodova Z., Jankovicova B., Horak D., Bilkova Z.
J. Anal. Bioanal. Tech. 4, 168 (2013)

DOI: 10.4172/2155-9872.1000168
   

On-line capillary electrophoresis derivatization method for high sensitivity analysis of ubiquitin in filtered cerebrospinal fluid

Kiarach Mesbah, Farid Oukacine, Stefan Lehnert, Markus Otto and Myriam Taverna
Electrophoresis 34, 2733-2739 (2013)

DOI: 10.1002/elps.201300155 PubMed: 23857291
   

Contribution of CE to the Analysis of Protein or Peptide Biomarkers

Kiarach Mesbah, Romain Verpillot, Francois de l'Escaille, Jean Bernard Falmagne and Myriam Taverna
Methods in Molecular Biology 984, 167-190 (2013)

DOI: 10.1007/978-1-62703-296-4_13 PubMed: 23386344
   

Analysis of Amino-Terminal Variants of Amyloid-β Peptides by Capillary Isoelectric Focusing Immunoassay

U Haußmann, O Jahn, P Linning, C Janßen, T Liepold, E Portelius, H Zetterberg, C Bauer, J Schuchhardt, HJ Knölker, H Klafki and J Wiltfang
Analytical Chemistry 85, 8142-9 (2013)

DOI: 10.1021/ac401055y PubMed: 23889568
   

Fabrication and characterization of tosyl - activated magnetic and non-magnetic monodisperse microspheres for use in microfluic-based ferritin immunoassay

F. Reymond, C. Vollet, Z. Plichta and D. Horák
Biotechnology progress 29, 532–542 (2013)

DOI: 10.1002/btpr.1683 PubMed: 23296798
   

Simple paper architecture modifications lead to enhanced sensitivity in nanoparticle based lateral flow immunoassays

C. Parolo, M. Medina-Sánchez, A. de la Escosura-Muñiz and A. Merkoçi
Lab on a Chip 13, 386–390 (2013)

DOI: 10.1039/C2LC41144J
   

Enhanced lateral flow immunoassay using gold nanoparticles loaded with enzymes

C. Parolo, A. de la Escosura-Muñiz and A. Merkoçi
Biosensors and Bioelectronics 40, 412-416 (2013)

DOI: 10.1016/j.bios.2012.06.049 PubMed: 22795532
   

Fabrication and bonding of thiol-ene-based microfluidic devices

Tiina M Sikanen, Josiane P Lafleur, Maria-Elisa Moilanen, Guisheng Zhuang, Thomas G Jensen and Jörg P Kutter
Journal of Micromechanics and Microengineering 23, 1-7 (2013)

DOI: 10.1088/0960-1317/23/3/037002
   

Development of a high-sensitivity immunoassay for amyloid-beta 1–42 using a silicon microarray platform

Paola Gagni, Laura Sola, Marina Cretich and Marcella Chiari
Biosensors and Bioelectronics 47,  490-495 (2013)

DOI: 10.1016/j.bios.2013.03.077 PubMed: 23624018
   

Surface immobilized hydrogels as versatile reagent reservoirs for microarrays

Sola L., Gagni P., Cretich M. and Chiari M.
Journal of Immunological Methods 391, 95-102 (2013)

DOI: 10.1016/j.jim.2013.02.013
   

Rapid photochemical surface patterning of proteins in thiol-ene based microfluidic devices

Josiane P. Lafleur, Radoslaw Kwapiszewski, Thomas G. Jensen and Jörg P. Kutter
Analyst 138, 845-849 (2013)

DOI: 10.1039/C2AN36424G PubMed: 23193537
   

Nanochannels for diagnostic of thrombin-related diseases in human blood

A. de la Escosura-Muñiz, W. Chunglok, W. Surareungchai, A. Merkoçi
Biosensors and Bioelectronics 40, 24-31 (2013)

DOI: 10.1016/j.bios.2012.05.021 PubMed: 22704840
   

The use of hydrophilic poly(N,N-dimethylacrylamide) grafted from magnetic gama-Fe2O3 nanoparticles to promote engulfment by mammalian cells

Zasonska B.A., Boiko N., Horák D., Klyuchivska O., Macková H., Beneš M., Babič M., Trchová M., Hromádková J. and Stoika R.
Journal of Biomedical Nanotechnology 9, 479-491 (2013)

DOI: 10.1166/jbn.2013.1552 PubMed: 23621005
   

PEG-modified Macroporous poly(glycidyl methacrylate) and poly(2-hydroxyethyl methacrylate) microspheres to reduce nonspecific protein adsorption

Hlídková H., Horák D., Proks V., Kučerová Z., Pekárek M., Kučka J.
Macromolecular Bioscience 13, 503–511 (2013)

DOI: 10.1002/mabi.201200446 PubMed: 23359599

2012

   

Analytical miniaturization and nanotechnologies

A. Merkoci and J. P. Kutter
Lab Chip, 2012,12, 1915-1916

DOI: 10.1039/C2LC90040H PubMed: 22543818
 

Fabrication of thermoplastics chips through lamination based techniques

Sandrine Miserere, Guillaume Mottet, Velan Taniga, Stephanie Descroix, Jean-Louis Viovy, and Laurent Malaquin
Lab Chip, 2012,12, 1849-1856  

DOI: 10.1039/C2LC21161K

 

   

Microchip Electrophoresis, with Respect to “Profiling of Aβ Peptides in the Cerebrospinal Fluid of Patients with Alzheimer’s Disease”

Mohamad Reza Mohamadi, Romain Verpillot, Myriam Taverna, Markus Otto, Jean-Louis Viovy
Methods Mol Biol. 2012;869:173-84

DOI: 10.1007/978-1-61779-821-4_14 PubMed: 22585485
 

Programmable magnetic tweezers and droplet microfluidic device for high-throughput nanoliter multi-step assays

Ali-Cherif A, Begolo S, Descroix S, Viovy JL, Malaquin L.
Angew Chem Int Ed Engl. 2012 Oct 22;51(43):10765-9

DOI: 10.1002/anie.201203862 PubMed: 23011819
 

Roadmap and standard operating procedures for biobanking and discovery of neurochemical markers in ALS

Otto, M., R. Bowser, M. Turner, J. Berry, J. Brettschneider, J. Connor, J. Costa, M. Cudkowicz, J. Glass, O. Jahn, S. Lehnert, A. Malaspina, L. Parnetti, A. Petzold, P. Shaw, A. Sherman, P. Steinacker, S. Süssmuth, C. Teunissen, H. Tumani, A. Wuolikainen and A. Ludolph
Amyotroph Lateral Scler. 2012 Jan;13(1):1-10

DOI: 10.3109/17482968.2011.627589 PubMed: 22214350
 

Genetic analysis of genes involved in amyloid-β degradation and clearance in Alzheimer's disease

Natunen T, Helisalmi S, Vepsäläinen S, Sarajärvi T, Antikainen L, Mäkinen P, Herukka SK, Koivisto AM, Haapasalo A, Soininen H, Hiltunen M.
J Alzheimers Dis. 2012;28(3):553-9 

DOI: 10.3233/JAD-2011-111109 PubMed: 22027013

 

 

Age and diagnostic performance of Alzheimer disease CSF biomarkers

Mattsson N, Rosén E, Hansson O, Andreasen N, Parnetti L, Jonsson M, Herukka SK, van der Flier WM, Blankenstein MA, Ewers M, Rich K, Kaiser E, Verbeek MM, Olde Rikkert M, Tsolaki M, Mulugeta E, Aarsland D, Visser PJ, Schröder J, Marcusson J, de Leon M, Hampel H, Scheltens P, Wallin A, Eriksdotter-Jönhagen M, Minthon L, Winblad B, Blennow K, Zetterberg H
Neurology. 2012 Feb 14;78(7):468-76 

DOI: 10.1212/WNL.0b013e3182477eed PubMed: 22302554
 

iTRAQ and multiple reaction monitoring as proteomic tools for biomarker search in cerebrospinal fluid of patients with Parkinson's disease dementia

Lehnert S, Jesse S, Rist W, Steinacker P, Soininen H, Herukka SK, Tumani H, Lenter M, Oeckl P, Ferger B, Hengerer B, Otto M
Exp Neurol. 2012 Apr;234(2):499-505 

DOI: 10.1016/j.expneurol.2012.01.024 PubMed: 22327139

 

 

CSF biomarkers for Alzheimer disease correlate with cortical brain biopsy findings

Seppälä TT, Nerg O, Koivisto AM, Rummukainen J, Puli L, Zetterberg H, Pyykkö OT, Helisalmi S, Alafuzoff I, Hiltunen M, Jääskeläinen JE, Rinne J, Soininen H,Leinonen V, Herukka SK
Neurology. 2012 May 15;78(20):1568-75

DOI: 10.1212/WNL.0b013e3182563bd0 PubMed: 22517093
   

Clinical use of cerebrospinal fluid biomarkers in Alzheimer's disease

Zetterberg H, Lunn MP, Herukka SK
Biomark Med. 2012 Aug;6(4):371-6 

DOI: 10.2217/bmm.12.47 PubMed: 22917139
 

Differential sialylation of serpin A1 in the early diagnosis of Parkinson's disease dementia

Jesse S, Lehnert S, Jahn O, Parnetti L, Soininen H, Herukka SK, Steinacker P, Tawfik S, Tumani H, von Arnim CA, Neumann M, Kretzschmar HA, Kulaksiz H, Lenter M, Wiltfang J, Ferger B, Hengerer B, Otto M
PLoS One. 2012;7(11):e48783 

DOI: 10.1371/journal.pone.0048783 PubMed: 23144969
   

Application of the PredictAD software tool to predict progression in patients with mild cognitive impairment

Simonsen AH, Mattila J, Hejl AM, Frederiksen KS, Herukka SK, Hallikainen M, van Gils M, Lötjönen J, Soininen H, Waldemar G
Dement Geriatr Cogn Disord. 2012;34(5-6):344-50 

DOI: 10.1159/000345554 PubMed: 23222123

 

 

Structural MRI in frontotemporal dementia: comparisons between hippocampal volumetry, tensor-based morphometry and voxel-based morphometry

Muñoz-Ruiz MÁ, Hartikainen P, Koikkalainen J, Wolz R, Julkunen V, Niskanen E, Herukka SK, Kivipelto M, Vanninen R, Rueckert D, Liu Y, Lötjönen J, Soininen H
PLoS One. 2012;7(12):e52531

DOI: 10.1371/journal.pone.0052531 PubMed: 23285078

 

   

Carbon nanotubes and graphene in analytical sciences

Briza Pérez-López and Arben Merkoçi
Microchimica Acta, October 2012, Volume 179, Issue 1, pp 1-16

DOI:10.1007/s00604-012-0871-9
 

Modulation of EOF in CE using functional polymer coatings

Sola L., Chiari M.
J Chromat A 1270, 324-329, (2012).  

Aminoterminally truncated and oxidized amyloid-beta peptides in the cerebrospinal fluid of Alzheimer's disease patients

Bibl M, Gallus M, Welge V, Esselmann H and Wiltfang J
Journal of Alzheimers Disease 29, 809-16 (2012)

DOI: 10.3233/JAD-2012-111796 PubMed: 22460324
   

On chip electrochemical detection of CdS quatum dots using normal and multiple recycling flow through modes

M. Medina-Sánchez, S. Miserere, S. Marín, G. Aragay and A. Merkoçi
Lab on a Chip 12, 2000-2005 (2012)

DOI: 10.1039/C2LC00007E PubMed: 22549234
 

 

Interferometric silicon biochips for label and label-free DNA and protein microarrays

M. Cretich , M.R. Monroe, A. Reddington, X. Zhang, G.G. Daaboul, F. Damin, L. Sola, M. S, Unlu and M. Chiari
Proteomics 12, 2963-2977 (2012)

DOI: 10.1002/pmic.201200202 PubMed: 22930463
   

Optimisation of BACE1 inhibition of tripartite structures by modification of membrane anchors, spacers and pharmacophores - development of potential agents for the treatment of Alzheimer's disease

P Linning, U Haussmann, I Beyer,  S Weidlich, H Schieb, J Wiltfang, HW Klafki, HJ Knölker
Organic Biomolecular Chemistry 10, 8216-8235 (2012)

DOI: 10.1039/C2OB26103K PubMed: 22930158
   

Development of a magnetic immunosorbent for on-chip preconcentration of amyloid beta isoforms: Representatives of Alzheimer's disease biomarkers

Svobodova Z, Reza Mohamadi M, Jankovicova B, Esselmann H, Verpillot R, Otto M, Taverna M, Wiltfang J, Viovy JL, Bilkova Z
Biomicrofluidics 6, 24126-2412612 (2012)

DOI: 10.1063/1.4722588 PubMed: 22712037
   

Cerebrospinal fluid amyloid-beta 2-42 is decreased in Alzheimer's, but not in frontotemporal dementia

Bibl M, Gallus M, Welge V, Esselmann H, Wolf S, Ruther E and Wiltfang J
Journal of Neural Transmission 119, 805-813 (2012)

DOI: 10.1007/s00702-012-0801-3 PubMed: 22527776
   

Neurochemical biomarkers in Alzheimer's disease and related disorders

Bibl M, Esselmann H and Wiltfang J
Therapeutic Advances in Neurological Disorders 5, 335-348 (2012). 

DOI: 10.1177/1756285612455367 PubMed: 23139704
   

New monodisperse magnetic polymer microspheres biofunctionalized for enzyme catalysis and bioaffinity separations

Horák D, Kučerová J, Korecká L, Jankovičová B, Palarčík J, Mikulášek P, Bílková Z
Macromolecular Bioscience 12, 647-655 (2012)

DOI: 10.1002/mabi.201100393 PubMed: 22411761
   

Nanochannels preparation and application in biosensing

A. de la Escosura-Muñiz and A. Merkoçi
ACS Nano 6, 7556–7583 (2012)

DOI: 10.1021/nn301368z PubMed: 22880686
   

Detection of circulating cancer cells using electrocatalytic gold nanoparticles

M. Maltez-da Costa, A. de la Escosura-Muñiz, C. Nogués, L. Barrios, E. Ibáñez and A. Merkoçi
Small 8, 3605-3612 (2012)

DOI: 10.1002/smll.201201205 PubMed: 22893274
   

Simple monitoring of cancer cells using nanoparticles

M. Maltez-da Costa, A. de la Escosura-Muñiz, C. Nogués, L. Barrios, E. Ibáñez and A. Merkoçi
Nano Letters 12, 4164-4171 (2012)

DOI: 10.1021/nl301726g
   

Nanoparticles for proteins and cells detection. Novel tools for clinical Diagnostics

A. de la Escosura-Muñiz and A. Merkoçi
G.I.T. Laboratory Journal 1-2, 21-23 (2012)

Link
   

Nanomaterials and lab-on-a-chip Technologies

M. Medina-Sánchez, S. Miserere and A. Merkoçi
Lab on a Chip 12, 1932–1943 (2012)

DOI: 10.1039/C2LC40063D
   

Signal Enhancement in antibody microarrays using Quantum Dots nanocrystals: application to potential Alzheimer’s disease biomarker screening

E. Morales-Narváez, H. Montón, A. Fomicheva and A. Merkoçi
Analytical Chemistry 84, 6821-6827 (2012)

DOI: 10.1021/ac301369e PubMed: 22732018
   

Simple Förster resonance energy transfer evidence for the ultrahigh quantum dot quenching efficiency by graphene oxide compared to other carbon structures

E. Morales-Narváez, B. Pérez-López, L. Pires and A. Merkoçi
Carbon 50, 2987-2993 (2012)

DOI: 10.1016/j.carbon.2012.02.081
   

Graphene Oxide as an Optical Biosensing Platform

E. Morales-Narváez and A. Merkoçi
Advanced Materials  24, 3298-32308 (2012)

DOI: 10.1002/adma.201200373 PubMed: 22628274
   

Use of magnetic hydrazide-modified polymer microspheres for enrichment of Francisella tularensis glycoproteins

Horák D., Balonová L., Mann B.F., Plichta Z., Hernychová L., Novotny M.V., Stulík J.
Soft Matter 8, 2775-2786 (2012)

DOI: 10.1039/C2SM07036G

2011

   

Metabolome in progression to Alzheimer's disease

Orešič M, Hyötyläinen T, Herukka SK, Sysi-Aho M, Mattila I, Seppänan-Laakso T, Julkunen V, Gopalacharyulu PV, Hallikainen M, Koikkalainen J, Kivipelto M, Helisalmi S, Lötjönen J, Soininen H
Transl Psychiatry. 2011 Dec 13;1:e57 

DOI: 10.1038/tp.2011.55 PubMed: 22832349

 

 

Longitudinal changes of CSF biomarkers in Alzheimer's disease

Seppälä TT, Koivisto AM, Hartikainen P, Helisalmi S, Soininen H, Herukka SK
J Alzheimers Dis. 2011;25(4):583-94

DOI:10.3233/JAD-2011-101911 PubMed: 21460434
 

Transcranial magnetic stimulation-evoked EEG/cortical potentials in physiological and pathological aging

Casarotto S, Määttä S, Herukka SK, Pigorini A, Napolitani M, Gosseries O, Niskanen E, Könönen M, Mervaala E, Rosanova M, Soininen H, Massimini M
Neuroreport. 2011 Aug 24;22(12):592-7 

DOI:10.1097/WNR.0b013e328349433a PubMed: 21753711

 

 

The Alzheimer's Association external quality control program for cerebrospinal fluid biomarkers

Mattsson N, Andreasson U, Persson S, Arai H, Batish SD, Bernardini S, Bocchio-Chiavetto L, Blankenstein MA, Carrillo MC, Chalbot S, Coart E, Chiasserini D, Cutler N, Dahlfors G, Duller S, Fagan AM, Forlenza O,Frisoni GB, Galasko D, Galimberti D, Hampel H, Handberg A, Heneka MT, Herskovits AZ, Herukka SK,Holtzman DM, Humpel C, Hyman BT, Iqbal K, Jucker M, Kaeser SA, Kaiser E, Kapaki E, Kidd D, Klivenyi P,Knudsen CS, Kummer MP, Lui J, Lladó A, Lewczuk P, Li QX, Martins R, Masters C, McAuliffe J, Mercken M,Moghekar A, Molinuevo JL, Montine TJ, Nowatzke W, O'Brien R, Otto M, Paraskevas GP, Parnetti L,Petersen RC, Prvulovic D, de Reus HP, Rissman RA, Scarpini E, Stefani A, Soininen H, Schröder J, Shaw LM, Skinningsrud A, Skrogstad B, Spreer A, Talib L, Teunissen C, Trojanowski JQ, Tumani H, Umek RM,Van Broeck B, Vanderstichele H, Vecsei L, Verbeek MM, Windisch M, Zhang J, Zetterberg H, Blennow K
Alzheimers Dement. 2011 Jul;7(4):386-395.e6

DOI:10.1016/j.jalz.2011.05.2243 PubMed: 21784349
 

Magnetic poly(propargylacrylamide) microspheres: Preparation by precipitation polymerization and use in model click reactions

Hana Macková, Vladimír Proks, Daniel Horák, Jan Kučka, and Miroslava Trchová
Polymer Chemistry, Volume 49, Issue 22, 15 November 2011, Pages 4820–4829

DOI:10.1002/pola.24930

Size-dependent direct electrochemical detection of gold nanoparticles: application in magnetoimmunoassays

A. de la Escosura-Muñiz, C. Parolo, F. Maran and A. Merkoçi
Nanoscale 3, 3350-3356 (2011)

DOI: 10.1039/C1NR10377F PubMed: 21761067
   

A nanochannel/nanoparticle-based filtering and sensing platform for direct detection of a cancer biomarker in blood

A. de la Escosura-Muñiz and A. Merkoçi,
Small 7, 675-682 (2011)

DOI: 10.1002/smll.201002349 PubMed: 21294272
   

Anti-stiction coating of PDMS moulds for rapid microchannel fabrication by double replica moulding

Guisheng Zhuang and Jörg P Kutter
Journal of Micromechanics and Microengineering 21, 1-6 (2011)

DOI: 10.1088/0960-1317/21/10/105020 Orbit
   

Surface-Initiated Polymerization of 2-Hydroxyethyl Methacrylate from Heterotelechelic Oligoperoxide-Coated γ-Fe2O3 Nanoparticles and their Engulfment by Mammalian Cells

Daniel Horák, Tetiana Shagotova, Nataliya Mitina, Miroslava Trchová, Nataliya Boiko, Michal Babič, Rostyslav Stoika, Jana Kovářová, Orest Hevus, Milan J. Beneš, Olga Klyuchivska, Petr Holler and Alexander Zaichenko
Chemistry of Materials  23, 2637–2649 (2011)

DOI: 10.1021/cm2004215
   

Immunomagnetic sulfonated hypercrosslinked polystyrene microspheres for electrochemical detection of proteins

Petr Sálek, Lucie Korecká, Daniel Horák, Eduard Petrovský, Jana Kovárová, Radovan Metelka, Michaela Cadková and Zuzana Bilková
Journal of Materials Chemistry 21, 14784-14792 (2011)

DOI: 10.1039/C1JM12475G
   

The Influence of Feature Selection Methods on Accuracy, Stability and Interpretability of Molecular Signatures

Anne-Claire Haury, Pierre Gestraud and Jean-Philippe Vert
PLoS ONE 6, e28210 (2011)

DOI: 10.1371/journal.pone.0028210 arXiv:1101.5008 
 

Voltammetric Detection of Ovalbumin at Screen-Printed Electrodes in Combination with Immunomagnetic Particles

Michaela Cadková, Lucie Korecká, Petr Šálek, Radovan Metelka and Zuzana Bílková
Sensing in Electroanalysis 6, 347-356 (2011)

   

New Method for Fabrication of Fused Silica Emitters with Submicrometer Orifices for Nanoelectrospray Mass Spectrometry

Patrik Ek and Johan Roeraade
Analytical Chemistry 83, 7771-7777 (2011)

DOI: 10.1021/ac201308n PubMed: 21939240

 2010

 

Neurofilament ELISA validation

Petzold A, Altintas A, Andreoni L, Bartos A, Berthele A, Blankenstein MA, Buee L, Castellazzi M, Cepok S, Comabella M, Constantinescu CS, Deisenhammer F, Deniz G, Erten G, Espiño M, Fainardi E, Franciotta D, Freedman MS, Giedraitis V, Gilhus NE, Giovannoni G, Glabinski A, Grieb P, Hartung HP, Hemmer B, Herukka SK, Hintzen R, Ingelsson M, Jackson S, Jacobsen S, Jafari N, Jalosinski M, Jarius S, Kapaki E, Kieseier BC, Koel-Simmelink MJ, Kornhuber J, Kuhle J, Kurzepa J, Lalive PH, Lannfelt L, Lehmensiek V, Lewczuk P, Livrea P, Marnetto F, Martino D, Menge T, Norgren N, Papuć E, Paraskevas GP, Pirttilä T, Rajda C, Rejdak K, Ricny J, Ripova D, Rosengren L, Ruggieri M, Schraen S, Shaw G, Sindic C, Siva A, Stigbrand T, Stonebridge I, Topcular B, Trojano M, Tumani H, Twaalfhoven HA, Vécsei L, Van Pesch V, Vanderstichele H, Vedeler C, Verbeek MM, Villar LM, Weissert R, Wildemann B, Yang C, Yao K, Teunissen CE
J Immunol Methods. 2010 Jan 31;352(1-2):23-31 

DOI: 10.1016/j.jim.2009.09.014 PubMed: 19857497
 

Differences in cortical thickness in healthy controls, subjects with mild cognitive impairment, and Alzheimer's disease patients: a longitudinal study

Julkunen V, Niskanen E, Koikkalainen J, Herukka SK, Pihlajamäki M, Hallikainen M, Kivipelto M, Muehlboeck S, Evans AC, Vanninen R, Hilkka Soininen
J Alzheimers Dis. 2010;21(4):1141-51 

DOI: 10.3233/JAD-2010-100114 PubMed: 21504134

 

 

Plasma Abeta42 and Abeta40 as markers of cognitive change in follow-up: a prospective, longitudinal, population-based cohort study

Seppälä TT, Herukka SK, Hänninen T, Tervo S, Hallikainen M, Soininen H, Pirttilä T
J Neurol Neurosurg Psychiatry. 2010 Oct;81(10):1123-7

DOI: 10.1136/jnnp.2010.205757 PubMed: 20478847

 

   

An association study of 21 potential Alzheimer's disease risk genes in a Finnish population

Sarajärvi T, Helisalmi S, Antikainen L, Mäkinen P, Koivisto AM, Herukka SK, Haapasalo A, Soininen H, Hiltunen M
J Alzheimers Dis. 2010;21(3):763-7

DOI: 10.3233/JAD-2010-100597 PubMed: 20693638

 

Discovery and use of efficient biomarkers for objective disease state assessment in Alzheimer's disease

van Gils M, Koikkalainen J, Mattila J, Herukka S, Lotjonen J, Soininen H
Conf Proc IEEE Eng Med Biol Soc. 2010;2010:2886-9

DOI: 10.1109/IEMBS.2010.5626311

PubMed:21095977

 2009

   
 

Expression of interleukin-18 is increased in the brains of Alzheimer's disease patients

Ojala J, Alafuzoff I, Herukka SK, van Groen T, Tanila H, Pirttilä T
Neurobiol Aging. 2009 Feb;30(2):198-209

PubMed:17658666

 

Cerebrospinal fluid {beta}-amyloid 42 and tau proteins as biomarkers of Alzheimer-type pathologic changes in the brain

Tapiola T, Alafuzoff I, Herukka SK, Parkkinen L, Hartikainen P, Soininen H, Pirttilä T
Arch Neurol. 2009 Mar;66(3):382-9 

DOI: 10.1001/archneurol.2008.596

PubMed:19273758

 

 

CSF biomarkers and incipient Alzheimer disease in patients with mild cognitive impairment

Mattsson N, Zetterberg H, Hansson O, Andreasen N, Parnetti L, Jonsson M, Herukka SK, van der Flier WM, Blankenstein MA, Ewers M, Rich K, Kaiser E, Verbeek M, Tsolaki M, Mulugeta E, Rosén E, Aarsland D, Visser PJ, Schröder J, Marcusson J, de Leon M, Hampel H, Scheltens P, Pirttilä T, Wallin A, Jönhagen ME, Minthon L, Winblad B, Blennow K
JAMA. 2009 Jul 22;302(4):385-93

DOI: 10.1001/jama.2009

PubMed:19622817

 2008

   
 

Genetic study evaluating LDLR polymorphisms and Alzheimer's disease

Lämsä R, Helisalmi S, Herukka SK, Tapiola T, Pirttilä T, Vepsäläinen S, Hiltunen M, Soininen H
Neurobiol Aging. 2008 Jun;29(6):848-55

PubMed:17239995

 

 

CSF Abeta42, tau and phosphorylated tau correlate with medial temporal lobe atrophy

Herukka SK, Pennanen C, Soininen H, Pirttilä T
J Alzheimers Dis. 2008 May;14(1):51-7 

PubMed:18525127

 

PET amyloid ligand [11C]PIB uptake and cerebrospinal fluid beta-amyloid in mild cognitive impairment

Koivunen J, Pirttilä T, Kemppainen N, Aalto S, Herukka SK, Jauhianen AM, Hänninen T, Hallikainen M, Någren K, Rinne JO, Soininen H
Dement Geriatr Cogn Disord. 2008;26(4):378-83

DOI: 10.1159/000163927

PubMed:18931497

 

2007

   
 

CSF Abeta42, Tau and phosphorylated Tau, APOE epsilon4 allele and MCI type in progressive MCI

Herukka SK, Helisalmi S, Hallikainen M, Tervo S, Soininen H, Pirttilä T
Neurobiol Aging. 2007 Apr;28(4):507-14 

DOI: 10.1016/j.neurobiolaging.2006.02.001

PubMed:16546302

 

The association study between DHCR24 polymorphisms and Alzheimer's disease

Lämsä R, Helisalmi S, Hiltunen M, Herukka SK, Tapiola T, Pirttilä T, Vepsäläinen S, Soininen H
Am J Med Genet B Neuropsychiatr Genet. 2007 Oct 5;144B(7):906-10

DOI: 10.1002/ajmg.b.30532

PubMed:17510943

2004

   
 

Longitudinal observation on CSF Abeta42 levels in young to middle-aged amyloid precursor protein/presenilin-1 doubly transgenic mice

Liu L, Herukka SK, Minkeviciene R, van Groen T, Tanila H
Neurobiol Dis. 2004 Dec;17(3):516-23. 

DOI: 10.1016/j.nbd.2004.08.005

PubMed:15571987

 

2003

   
   

Abeta levels in serum, CSF and brain, and cognitive deficits in APP + PS1 transgenic mice

Liu L, Tapiola T, Herukka SK, Heikkilä M, Tanila H
Neuroreport. 2003 Jan 20;14(1):163-6. 

PubMed:12544850

http://www.fp7nadine.eu/results/publications/peer-reviewed
21 OCTOBER 2017