KTH is the largest technical university in Sweden (more than 12.000 students). The Department of Analytical Chemistry (DAC) consists of ca 15 persons, and belongs to the School of Chemical Science and Engineering. The major part of the research at the Department is focused on frontline development and use of miniaturized analytical systems, mainly for biochemical and biomedical applications. The Department has a long history in this field, and has a large network of national and international collaborations.
DAC has several unique microfluidic systems, e.g. a novel nanorobotic platform for automated handling of very small sample volumes ( pL and below) and new, innovative microdispensing technologies. Particularly relevant for the project are the mass spectrometry facilities of the Department, which include MALDI-TOF with chip-based targets as well as MS-MS, equipped with a unique, adjustable nano-E-spray.
Novel sample introduction methods for mass spectrometry are being developed by DAC, to provide an unprecedented improvement in sensitivity. Chemistry in ultra-small droplets ( pL – fL), including a development of novel sample concentration and sample handling technologies for low-level proteins is another activity at the Department. New miniaturized separation techniques are also being developed, e.g. a new concept for ultra- purification of oligonucleotides.